Substance in Marijuana Could Benefit Alzheimer’s Patients
FILE – One hemisphere of a healthy brain (L) is pictured next to one hemisphere of a brain of a person suffering from Alzheimer disease.
June 30, 2016 2:00 PM
A substance found in marijuana might remove a kind of plaque associated with Alzheimer’s disease, according to a new study.
Writing in the journal Aging and Mechanisms of Disease, researchers from the Salk Institute say that the chemical THC (tetrahydrocannabinol) and other active components of marijuana can “promote the cellular removal of amyloid beta, a toxic protein associated with Alzheimer’s disease” in neurons grown in a lab.
“Although other studies have offered evidence that cannabinoids might be neuroprotective against the symptoms of Alzheimer’s, we believe our study is the first to demonstrate that cannabinoids affect both inflammation and amyloid beta accumulation in nerve cells,” said Salk Professor David Schubert, the senior author of the paper.
Alzheimer’s is a degenerative brain disease leading to memory loss and dementia. According to the National Institutes of Health, it affects more than 5 million Americans.
Amyloid beta accumulation in nerve cells has been associated with Alzheimer’s, and it usually appears before symptoms of the disease, but researchers remain unsure how it forms.
For their study, Salk Institute researchers looked at nerve cells which had been altered to produce higher than normal amounts of amyloid beta.
They found that higher levels of the substance “were associated with cellular inflammation and higher rates of neuron death.”
However, when exposed to THC, the levels of amyloid beta decreased, eliminating the “inflammatory response.”
“Inflammation within the brain is a major component of the damage associated with Alzheimer’s disease, but it has always been assumed that this response was coming from immune-like cells in the brain, not the nerve cells themselves,” said Antonio Currais, a postdoctoral researcher in Schubert’s laboratory and first author of the paper.
“When we were able to identify the molecular basis of the inflammatory response to amyloid beta, it became clear that THC-like compounds that the nerve cells make themselves may be involved in protecting the cells from dying.”
While the tests were only done on cells in a lab, the researchers think further study could result in “novel therapeutics” to combat Alzheimer’s.